1. Selecting drug targets in contemporary Human pathogenic diseases and screening them across a database of antimicrobial peptides for plausible therapeutic interventions
by
Ms. Puspita Giri, MSc Bioinformatics, MAKAUT, WB, India (Linkedin)
1. Serving as a joint-supervisor for the doctoral project entitled Temperature Dependent Conformers of SYMRK and their Structure-Function Relationship
with
Prof. Maitrayee DasGupta, Department of Biochemistry, University of Calcutta, Kolkata, India. (Linkedin)
(OPEN POSITION) Interested students with a Junior Research Fellowship may choose to Apply
2. Exploring Peptides with the potential to block SARS-CoV-2 variants
by
Swati Kundu, Bristi Saha, Ankit Roy, BSc students, Microbiology, Asutosh College, Kolkata, WB, India
3.
The evolutionary bridge between Multi-functional and Intrinsically Disordered Proteins
Intrinsic flexibility and structural transitions in IDPs underpin their multifunctionality, allowing disorder-to-order shifts upon binding diverse partners. Evolutionary diversification of protein structure-function relationships fosters complex, multi-layered functionalities beyond traditional enzyme roles. This project explores the pivotal role of IDPs in expressing protein versatility and adaptability.
by
Asifa Aftab, BSc student, Zoology, Asutosh College, Kolkata, WB, India (Linkedin)
Souradeep Sil, MSc student, Molecular and Human Genetics, Osmania University, Hyderabad, Telangana, India (Linkedin)
Seema Nath, Faculty, University of Texas Health Science Center at San Antonio, Texas, USA (Linkedin)
Anirneya Basu, BSc student, Microbiology, Asutosh College, Kolkata, WB, India (Linkedin)
Publications: Intrinsic Disorder and Other Malleable Arsenals of Evolved Protein Multi-functionality,
Journal of Molecular Evolution (2024), DOI: https://doi.org/10.1007/s00239-024-10196-7 (pdf)
4.
In-silico Analysis of Essential Oils as Tea Pest Insecticides
Computational methods to screen and evaluate the efficacy of essential oils as natural insecticides against common tea pests. Molecular modeling against proteins of interest identifies key compounds with pesticidal activity and assesses their interactions with target insect proteins. Results will support the development of sustainable, eco-friendly pest management strategies for tea cultivation.
with
Dr. Alok Hazra, Chromogen, Kolkata, India. Souradeep Sil, MSc student, Molecular and Human Genetics, Osmania University, Hyderabad, Telangana, India (Linkedin)
5.
& Molecular Dynamic Simulation of SYMRK "Thiol switch" from "Lock" to "Break" Conformation.
Molecular dynamics simulations investigate the conformational changes of the SYMRK protein's “thiol switch” mechanism, modeling the transition from "lock" to "break" states. Insights into the regulatory processes governing SYMRK activity enhance understanding of symbiotic signaling pathways and inform potential interventions in plant-microbe interactions.
with
Prof. Maitrayee DasGupta, Department of Biochemistry, University of Calcutta, Kolkata, India. (Linkedin)
Souradeep Sil, MSc student, Molecular and Human Genetics, Osmania University, Hyderabad, Telangana, India (Linkedin)
6.
Screening for Bio-therapeutics against Rabies Drug-Targets from Anti-Microbial Peptides and Essential Oil Compounds
A library of antimicrobial peptides and essential oil compounds is screened for bio-therapeutic agents targeting key proteins involved in rabies infection. In-silico docking and virtual screening identify candidates with strong binding affinity and inhibitory potential, paving the way for novel rabies treatments based on natural bioactive compounds.
with
Ishita Datta, MSc student, Department of Genetics & Plant Breeding, Benaras Hindu University, Uttar Pradesh, India. (Linkedin)
Souradeep Sil, MSc student, Molecular and Human Genetics, Osmania University, Hyderabad, Telangana, India (Linkedin)
7.
Molecular Docking Analysis of GF19 Peptide onto TRPV1 Ion Channel Receptor
Binding interactions between the GF19 peptide and the TRPV1 ion channel receptor are elucidated using molecular docking techniques. Key interaction sites and binding affinities are identified, offering insights into the modulation of TRPV1 activity. These findings suggest potential therapeutic strategies for pain management and inflammatory diseases.
with
May Griffith, Professeur titulaire, Departement dophtalmologie, Universite de Montreal
Souradeep Sil, MSc student, Molecular and Human Genetics, Osmania University, Hyderabad, Telangana, India (Linkedin)
Natalia Callai-Silva, PhD scholar, Universite de Montréal, Institute of Biomedical Engineering
8.
Secondary Structure Prediction of Collagen-Like Peptides (CLPs) for Biomedical Applications
Using AlphaFold3 to predict the secondary structures of collagen-like peptides (CLPs). Accurate structural models facilitate the development of CLP-based biomaterials for applications such as tissue engineering and wound healing, optimizing their performance in biomedical contexts.
with
May Griffith, Professeur titulaire, Departement dophtalmologie, Universite de Montreal
Souradeep Sil, MSc student, Molecular and Human Genetics, Osmania University, Hyderabad, Telangana, India (Linkedin)
Natalia Callai-Silva, PhD scholar, Universite de Montreal, Institute of Biomedical Engineering